Abstract
This review assesses the current landscape of hemophilia management, focusing on identifying unmet clinical needs. Hemophilia, a rare genetic bleeding disorder, requires continuous and comprehensive care to improve patients' life expectancy and quality of life (QoL). Despite advancements in treatment, challenges persist, including suboptimal bleed protection with current prophylactic options, the development of inhibitory alloantibodies, and the resulting joint damage leading to hemophilic arthropathy (HA). Additionally, the review highlights the significant physical and psychological burden on patients, impacting their education, employment, and overall QoL. Addressing these unmet needs through innovative therapies, improved access to care, and individualized treatment strategies is crucial for enhancing outcomes and reducing the overall burden of hemophilia, particularly in high-prevalence regions like India.